A new plastic bone filler material, utilizing adhesive carriers and human bone matrix particles, will be developed, and subsequent animal testing will assess its safety and capacity to induce bone formation.
Starting with voluntarily donated human long bones, decalcified bone matrix (DBM) was produced through crushing, cleaning, and demineralization. This DBM was then transformed into bone matrix gelatin (BMG) using a warm bath. A combination of BMG and DBM constituted the experimental group's plastic bone filler material, with DBM serving as the control group. Using fifteen healthy male thymus-free nude mice, aged 6-9 weeks, the intermuscular space between the gluteus medius and gluteus maximus muscles was prepared, and each animal received implantation of experimental group materials. Following surgical procedures, the animals were sacrificed at 1, 4, and 6 weeks, and HE staining analysis evaluated the ectopic osteogenic effect. Using eight 9-month-old Japanese large-ear rabbits, 6-mm-diameter defects were created in the condyles of both hind legs, with the left leg receiving the experimental materials and the right leg the control materials. The animals were sacrificed 12 and 26 weeks after the operation, in order to evaluate the effectiveness of bone defect repair, using Micro-CT and HE staining.
Results from HE staining in the ectopic osteogenesis experiment demonstrated the presence of a large quantity of chondrocytes one week post-operation, and a clear indication of newly formed cartilage tissue at four and six weeks post-surgical intervention. selleck chemical Twelve weeks after the rabbit condyle bone filling operation, HE staining showed absorption of certain materials, accompanied by the presence of new cartilage in both the experimental and control groups. The micro-CT examination indicated that the experimental group exhibited enhanced bone formation rates and areas when compared to the control group. Bone morphometric parameter measurements at 26 weeks post-operation demonstrated statistically significant increases in both groups compared to the measurements taken at 12 weeks post-operation.
Rewritten with care, this sentence's structure is rearranged, presenting a novel interpretation. Twelve weeks after the procedure, the experimental group exhibited significantly higher bone mineral density and bone volume fraction values than the control group.
Between the two groups, no significant difference in trabecular thickness was observed.
The specified numerical value exceeds zero point zero zero five. selleck chemical Following 26 weeks of postoperative monitoring, the experimental group's bone mineral density showed a statistically significant elevation relative to the control group.
From the depths of the profound to the surface of the mundane, life's experiences paint a vivid panorama. A comparative analysis of bone volume fraction and trabecular thickness revealed no substantial disparity between the two cohorts.
>005).
The novel plastic bone filler material exhibits exceptional biosafety and osteoinductive properties, making it an excellent bone-filling substance.
An excellent bone filler, the new plastic material demonstrates substantial biosafety and noteworthy osteoinductive activity.
An examination of the efficacy of V-shaped calcaneal osteotomy, coupled with subtalar arthrodesis, in managing Stephens and calcaneal fracture malunions.
Retrospectively, clinical data were examined for 24 patients with severe calcaneal fracture malunion, who received treatment combining calcaneal V-shaped osteotomy and subtalar arthrodesis, from January 2017 to December 2021. Twenty men and four women were present, having an average age of 428 years, within a range of 33 to 60 years. In 19 instances, conservative calcaneal fracture treatment proved unsuccessful, while surgery also yielded no positive outcome in 5 cases. Stephens' classification of calcaneal fracture malunion demonstrated 14 cases as type A and 10 cases as type B. The calcaneus's Bohler angle, measured preoperatively, demonstrated a mean of 86 degrees within a range of 40 to 135 degrees. In contrast, the preoperative Gissane angle exhibited a mean of 119.3 degrees, spanning a range from 100 to 152 degrees. The interval from the initial injury to the surgical procedure lasted between 6 and 14 months, yielding a mean of 97 months. Pre-operative and final follow-up effectiveness was assessed employing the American Orthopedic Foot and Ankle Society (AOFAS) ankle and hindfoot score and the visual analogue scale (VAS) score. Observations of bone healing and recordings of the healing time were made. Measurements were taken of the talocalcaneal height, talus inclination angle, pitch angle, calcaneal width, and hindfoot alignment angle.
Three cases demonstrated cuticle edge necrosis at the incision site, which were effectively managed by a combination of antibiotic therapy and dressing changes. The other incisions, through the process of primary union, experienced complete healing. All 24 patients experienced a follow-up period ranging from 12 to 23 months, resulting in an average duration of 171 months. Remarkably, the foot shape of the patients recovered completely, allowing the shoes to fit as they did before the injury, and eliminating any anterior ankle impingement. All patients experienced bone fusion, with recovery times spanning from 12 to 18 weeks, yielding an average healing period of 141 weeks. The final follow-up data showed that no patient exhibited adjacent joint degeneration. Five patients experienced mild foot pain while walking; however, this did not significantly impact their everyday lives or work. Surgery was not required in any case. The AOFAS ankle and hindfoot score demonstrated a significant elevation compared to the preoperative value.
The results of the study, from the 16 cases, were excellent; a further 4 demonstrated good results, while 4 displayed poor outcomes. The overall success rate, comprising excellent and good outcomes, reached an extraordinary 833%. The operation yielded a statistically significant improvement in the VAS score, talocalcaneal height, talus inclination angle, pitch angle, calcaneal width, and hindfoot alignment angle.
0001).
A V-shaped osteotomy of the calcaneus, coupled with subtalar arthrodesis, proves effective in alleviating hindfoot discomfort, rectifying talocalcaneal height, restoring the talar inclination angle, and diminishing the likelihood of nonunion following subtalar arthrodesis procedures.
A calcaneal V-shaped osteotomy, when performed alongside subtalar arthrodesis, is capable of relieving hindfoot pain, correcting the talocalcaneal height, restoring the talus inclination angle, and mitigating the possibility of nonunion post-subtalar arthrodesis.
Comparing three novel internal fixation methods for treating bicondylar four-quadrant tibial plateau fractures using finite element analysis, this study aimed to identify the method achieving the most consistent biomechanical performance in accordance with mechanical principles.
Utilizing computed tomography (CT) image data from a healthy male volunteer's tibial plateau, a three-dimensional bicondylar four-quadrant fracture model of the tibial plateau, and three different experimental internal fixation methods, were established through finite element analysis software. The anterolateral tibial plateaus of patient cohorts A, B, and C were fixed in place using inverted L-shaped anatomic locking plates. selleck chemical Group A's anteromedial and posteromedial plateaus were longitudinally anchored with reconstruction plates, and an oblique reconstruction plate was used to attach the posterolateral plateau. The medial proximal tibia was stabilized using a T-shaped plate in both groups B and C. The posteromedial plateau was secured longitudinally with a reconstruction plate, whereas the posterolateral plateau was fixed obliquely with a reconstruction plate. In three groups, the 1200 N axial load simulated a 60 kg adult walking with physiological gait on the tibial plateau, enabling calculation of the maximum fracture displacement and the maximum Von-Mises stress of the tibia, implants, and fracture line.
Stress concentration in the tibia, as determined by finite element analysis, was localized at the intersection of the fracture line and screw thread in all groups; the implant's stress concentration zones were found at the junction between screws and fracture fragments. In the three groups, fracture fragment maximum displacement remained consistent under a 1200-newton axial load; group A had the largest displacement (0.74 mm), and group B had the smallest (0.65 mm). Group C's implants demonstrated a significantly lower maximum Von-Mises stress (9549 MPa) than those in group B, which showed a maximum Von-Mises stress of 17796 MPa. Group C's tibia exhibited the least maximum Von-Mises stress (4335 MPa), standing in stark contrast to group B's highest maximum Von-Mises stress of 12050 MPa. Group A's fracture line demonstrated the minimum Von-Mises stress (4260 MPa), contrasting significantly with group B's fracture line, which showed the maximum stress, valued at 12050 MPa.
A T-plate secured to the medial tibial plateau in a bicondylar four-quadrant tibial plateau fracture demonstrates a more robust supporting effect than the use of two reconstruction plates affixed to the anteromedial and posteromedial plateaus, which should act as supplementary support. The auxiliary reconstruction plate, when positioned longitudinally within the posteromedial plateau, facilitates a more effective anti-glide effect compared to oblique fixation in the posterolateral plateau, ultimately contributing to a more stable biomechanical framework.
For a bicondylar four-quadrant tibial plateau fracture, fixing a T-shaped plate to the medial tibial plateau yields greater support compared to employing two reconstruction plates in the anteromedial and posteromedial plateaus, which should serve as the primary plate fixation. Though auxiliary in function, the reconstruction plate's anti-glide characteristics are more easily realized by longitudinal fixation in the posteromedial plateau than by oblique fixation in the posterolateral plateau. This facilitates the formation of a more stable and predictable biomechanical framework.